A comprehensive review on physicochemical, pharmacological and analytical profile of curcumin

Kavita Rohilla (1) , Sunita ahlawat (2) , Manjusha Choudhary (3) , Vikas Budhwar (4)
(1) Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana 124001, India, India ,
(2) Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana 124001, India, India ,
(3) Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana 136118, India, India ,
(4) Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana 124001, India, India


In the rhizomes of curcuma longa (family zinziberaceae), curcumin is present as a pigment, due to which it has importance in spices, cosmetics and drugs. It shows a variety of biological and physiological activities, like anti-tumour, anti-inflammatory, antiviral, anti-oxidant, anti-HIV etc. It has low toxicity at higher doses and is well tolerated by the human body. In spite of the proven research that supports the medicinal benefits of curcumin, its medicinal uses are countered by its low aqueous solubility and potential to get degraded in the GIT, which ultimately contributes towards its poor bioavailability. The present review summarizes the uses and applications of curcumin in drugs and cosmetics, briefly describing its status in folk medicines. It also mentions the methods of its analysis in drugs and cosmetics formulations and foodstuffs. The use of turmeric in ayurvedic medicines is described with their recipe and references. From the ancient times, turmeric is being used in various cosmetic preparations. In Indian rituals, turmeric is an essential component. In this review, various uses of the turmeric in cosmetics is mentioned. Ongoing recent research in these spheres is also summarised with references. In this review, the drawbacks of curcumin are also mentioned. As we know that turmeric is an ancient herb and have very beneficial properties beside this, it has some drawbacks, some negative properties etc. In the present review, we have discussed about various pharmacological, pharmacokinetic and medicinal properties of the curcumin and all this is summarized with the help of text, tables and figures. Various historical researches about curcumin are mentioned, including information about the discovery. 

Full text article

Generated from XML file


Aggarwal, B. B., Gupta, S. C., Sung, B. 2013. Curcumin: an orally bioavailable blocker of TNF and other proinflammatory biomarkers. British Journal of Pharmacology, 169(8):1672–1692.

Anand, P., Kunnumakkara, A. B., Newman, R. A., Aggarwal, B. B. 2007. Bioavailability of Curcumin: Problems and Promises. Molecular Pharmaceutics, 4(6):807–818.

Budhwar, V., Vikas, Y., Manjusha, C. 2018. Cyclodextrin Complexes: An approach to improve the physicochemical properties of drugs and applications of cyclodextrin complexes. Asian Journal of Pharmaceutics, 12(2):394–409.

Burgos-Morón, E., Calderón-Montaño, J. M., Salvador, J., Robles, A., López-Lázaro, M. 2010. The dark side of curcumin. International Journal of Cancer, 126(7).

Cui, J., Yu, B., Zhao, Y., Zhu, W., Li, H., Lou, H., Zhai, G. 2009. Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems. International Journal of Pharmaceutics, 371(1-2):148–155.

Fugita, R. A., Gálico, D. A., Guerra, R., Perpetuo, G. 2012. Thermal behaviour of Curcumin. Brazilian Journal of Thermal Analysis, 1(1):19-23.

Gordon, O. N., Luis, P. B., Schneider, C. 2015. Unravelling curcumin degradation: autoxidation proceeds through spiro epoxide and vinyl ether intermediates en route to the main bicyclopentadione. Journal of biological chemistry, 290(8):4817–4828.

Heger, M., van Golen, R. F., Broekgaarden, M., Michel, M. C. 2014. The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer. Pharmacological Reviews, 66(1):222–307.

Hewlings, S., Kalman, D. 2017. Curcumin: A Review of Its Effects on Human Health. Foods, 6(10):92– 92.

Kole, P. L., Jadhav, H., Nagappa, A. 2005. The cosmetic potential of herbal extracts. Natural product radiance, 4(4):315–321.

Lavanya, M., Jyothi, B. 2016. Performance Analysis of 5-Phase Multi-level Inverter Using Carrier Based PWM Technique.

Liu, W., Zhai, Y., Heng, X., Che, F. Y., Zhai, G. 2016. The oral bioavailability of curcumin: problems and advancements. Journal of drug targeting, 24(8):694–702.

Ma, G., Wang, Z., Du, G. 2018. Preparation and properties of stearic acid–acetanilide eutectic mixture/ expanded graphite composite phase-change material for thermal energy storage. Energy Technology, 6(1):153–160.

Maradana, M. R., Thomas, R., O’Sullivan, B. J. 2013. Targeted delivery of curcumin for treating type 2 diabetes.

Nimiya, Y., Wang, W., Du, Z., Sukamtoh, E., Zhu, J., Decker, E., Zhang, G. 2016. Redox modulation of curcumin stability: Redox active antioxidants increase chemical stability of curcumin. Molecular Nutrition & Food Research, 60:487–494.

Pawar, H., Karde, M., Mehra, K. 2014. Phytochemical evaluation and curcumin content determination of turmeric rhizomes collected from Bhandara District of Maharashtra (India). Medicinal Chemistry, 4(8):588–591.

Prasad, S., Tyagi, A. K., Aggarwal, B. B. 2014. Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice. Cancer Research and Treatment, 46(1):2–18.

Rahmani, A. H., Zohairy, M. A. A., Aly, S. M., Khan, M. A. 2014. Curcumin: A Potential Candidate in Prevention of Cancer via Modulation of Molecular Pathways. BioMed Research International, 2014(9):1–15.

Ravichandran, R. 2013. Studies on Dissolution Behaviour of Nanoparticulate Curcumin Formulation. Advances in Nanoparticles, 02(01):51–59.

Ravindranath, V., Chandrasekhara, N. 1980. Absorption and tissue distribution of curcumin in rats. Toxicology, 16(3):259–265.

Sanidad, K. Z., Sukamtoh, E., Xiao, H., McClements, D. J., Zhang, G. 2019. Curcumin: Recent Advances in the Development of Strategies to Improve Oral Bioavailability.

Shen, L., Ji, H. F. 2012. The pharmacology of curcumin: is it the degradation products? Trends in molecular medicine, 18(3):138–144.

The Ayurvedic Pharmacopoeia of India 2016. Ghaziabad: Pharmacopoeia Commission for Indian Medicine & Homoeopathy. Government of India ministry of health and family welfare department of Ayush, 1(1):60–61.

Vareed, S. K., Kakarala, M., Ruffin, M. T., Crowell, J. A., Normolle, D. P., Djuric, Z., Brenner, D. E. 2008. Pharmacokinetics of Curcumin Conjugate Metabolites in Healthy Human Subjects.

Wang, Y. J., Pan, M. H., Cheng, A. L., Lin, J. K. 1997. Stability of curcumin in buffer solutions and the characterization of its degradation products. Journal of pharmaceutical and biomedical analysis, 15(12):2024–2033.

Wichitnithad, W., Jongaroonngamsang, N., Pummangura, S., Rojsitthisak, P. 2009. A simple isocratic HPLC method for the simultaneous determination of curcuminoids in commercial turmeric extracts. Phytochemical Analysis, 20(4):314–319.


Kavita Rohilla
Sunita ahlawat
Manjusha Choudhary
Vikas Budhwar
vikaasbudhwar@yahoo.com (Primary Contact)
Kavita Rohilla, Sunita ahlawat, Manjusha Choudhary, & Vikas Budhwar. (2021). A comprehensive review on physicochemical, pharmacological and analytical profile of curcumin. International Journal of Research in Pharmaceutical Sciences, 12(2), 987–998. Retrieved from https://ijrps.com/home/article/view/66

Article Details

Most read articles by the same author(s)

No Related Submission Found